Abstract: Based on self-developped parallel software platform PANDA, algorithm design and parallel implementation of multipoint-base-excited harmonic response were carried out via modal superposition method. Corresponding parallel solution module was constructed, rightness of which is validated by comparisons with commercial FE software. Parallel module was successfully applied to harmonic response analysis of SG facility. An effective parallel solution of extensive computing scale up to 1.188 billion DOFs was achieved. It shows that parallel solution module is suitable to large-scale refined harmonic response analysis of complex equipments, behaving a strong parallel computing scalability up to thousands of CPU processors, and going far beyond the scale of commercial FE software.