Abstract: Physics-Informed Neural Networks (PINN) have provided a new way of numerically solving forward and inverse problems of partial differential equations with promising applications. This paper focuses on the diffusion coefficient inverse problem of the diffusion equation. A systematic study is carried out for the problems of fixed coefficients, anisotropic coefficients, spatial dependence coefficients, spatio-temporal dependence coefficients, and nonlinear diffusion coefficients, and the neural network structure and solution method required for solving each type of problem are proposed. Numerical experiments show that the PINN method can reconstruct the unknown coefficients accurately with less data and is robust under a certain noise level.