Abstract: We solve Navier-Stokes equation with chemical source term, focusing on effect of three oxygen-hydrogen chemical reaction mechanisms on ignition, combustion efficiency and area compression ratio of reactive shock bubble interaction(RSBI). These chemical reaction mechanisms are Evans-Schexnayder(ES) model, Jachimowski(J) model, Ó Conaire(Ó) model, respectively. Results simulated with ES model show that subjected to shock wave, bubble has the largest ignition delay; the lowest balanced temperature and its ignition position is different from J model and Ó model.Dimensionless area is adopted to characterize shape of bubble under effect of shock and combustion. It shows that simulation of bubble area is closely related to chemical reaction model after stage of heat release, and J model has the highest dilation rate. In simulating combustion efficiency of long-term RSBI flow field, differences among chemical reaction models are relatively decreased. As ES model fails to reveal ignition position correctly, J model and Ó model are suitable for simulating RSBI.