Abstract: We applie adaptive multi-resolution method to numerical simulation of stiffened-gas equation of state based on CJ model. A conservation sharp interface method of multiphase flow, in which the interface problem is tracked and solved by level-set method and ghost fluid method, is adopted. This method handles long physical time scale interactions across interface well and reduces conservative associated errors. In addition, pyramid data structure and adaptive multi-resolution analysis are used to improve storage efficiency and calculation efficiency of the algorithm. Finally, numerical examples are given to demonstrate stability and effectiveness of the adaptive multi-resolution method in numerical simulation of reactive multiphase flows.